PT673. Pharmacological analysis of nicotine-induced tremor

s | 45 Methods: Gabapentin 10, 30mg/kg; diclofenac 5mg/kg(reference drug), vehicle(saline) were injected intraperitoneally before 100μl of 1% carrageenan administration into the right hind paws of the rats. Paw thickness was measured by a gauge calipers(Vernier Calipers) before (0th hour) and in every hour during 6 hours after induction of inflammation. Paw thickness of treated groups were compared with control group with Oneway ANOVA. Also paw thickness in 0th and 6th hours were compared within each group with two-way ANOVA. Gabapentin was administered orally for 10 days to evaluate gastric side effect. At the end of 10 day treatment, rats were sacrificed, gastric tissues were removed out, mucus secretion was determined spectrophotometrically. Results: There was no significant difference between 0th and 6th hours in paw thickness of all groups, except carrageenan group. Carrageenan significantly increased paw thickness in 6th hour compared to 0th hour. All doses of gabapentin and diclofenac significantly reduced paw thickness in 6th hour compared to carrageenan group. Gabapentin 10 and 30mg/kg similar to diclofenac significantly reduced mucus secretion compared to control. Conclusion: We suggest that gabapentin as an antinociceptive effective agent may also possess antiinflammatory features. Both doses of gabapentin showed antiinflammatory effect and reduced gastric mucus secretion similar to diclofenac.